Effects of Postoperative Residual Paralysis on Hospital Costs

• Conditions: Residual Paralysis, Post-Anesthesia
• Interventions: Procedure: Quantitative measurement of neuromuscular transmission

• Registration Number: NCT01718860
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

This is a secondary analysis of a previously performed prospective, observer-blinded, observational study at Massachusetts General Hospital. The primary aim of this study is to evaluate the effects of residual paralysis at admission to the post-anesthesia care unit (PACU) on total costs of hospital care.

Secondary analyses will be conducted to evaluate the effects of postoperative residual paralysis on potential cost-influencing factors, i.e. incidence of minor and major postoperative respiratory complications, hospital length of stay (LOS), unplanned intensive care unit (ICU) admission rate, as well as length of stay in the PACU.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04
• Study First Submitted: 2012-10-29
• Study First Submitted QC: 2012-10-29
• Study First Posted: 2012-10-31
• Primary Completion: 2014-02
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-01
• Last Update Posted: 2017-05-04
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Each subject has been given non-depolarizing neuromuscular blocking agents as part of general anesthesia.
• Each subject must be at least 18 years of age
• Train-of-four monitoring in the post-anesthesia care unit

Exclusion Criteria

• The subject is scheduled to be transferred to an intensive care unit after surgery.
• Children and pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Postoperative Residual Paralysis	Quantitative measurement of neuromuscular transmission	Patients with train-of-four ratio less than 0.9 measured in the postanesthesia care unit
No Postoperative Residual Paralysis	Quantitative measurement of neuromuscular transmission	Patients with train-of-four ratio greater than 0.9 measured in the postanesthesia care unit

Primary Outcome Measures

Name	Time	Method
Hospital costs	Patients will be followed from date of admission to date of hospital discharge, an expected 2 days to 4 weeks

Secondary Outcome Measures

Name	Time	Method
Hospital Length of Stay	within 100 days after surgery

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States