Melatonin rhythm in older ICU patients

Completed

Conditions: Delirium, circadian rhythm, acute confusional state, ICU delirium, delier, acute verwardheid, melatonin, melatonine, circadiane ritme, elderly, ouderen

Registration Number: NL-OMON24047

Lead Sponsor: Academic Medical Centre Amsterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 142

Inclusion Criteria

Age 60 years or above
- Patients or their legal representative must be able to give informed consent
- Inclusion directly after ICU admission, but at least within 24 hours of admission
- Expected admission to the ICU for longer than one day
- Medical or surgical reason for admission to the IC

Exclusion Criteria

- Stroke as the reason for hospital admission
- Chronic use of antidepressants or antipsychotics before ICU admission
- Use of melatonin before or during hospital admission
- Dialysis before admission
- History of diagnosed dementia
- Absence of arterial or venous catheter

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the peak concentration and the secretion patterns of melatonin of older persons admitted to the ICU with and without delirium during the study days at a maximum of seven consecutive days.

Secondary Outcome Measures

Name	Time	Method
To investigate whether, besides delirium, mechanical ventilation, renal failure, sepsis or (nor) adrenergic stimulation influence melatonin in patients admitted to the IC