Melatonin rhythm in older ICU patients with and without delirium

Completed

Conditions: delirium
10012221
acute confusial state

Registration Number: NL-OMON41099

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 142

Inclusion Criteria

- Age 60 years or above
- Patients or their legal representative must be able to give informed consent
- Inclusion directly after ICU admission, but at least within 24 hours of admission
- Expected admission to the ICU for longer than one day
- Medical or surgical reason for admission to the ICU

Exclusion Criteria

- Stroke as the reason for hospital admission
- Chronic use of antidepressants or antipsychotics before ICU admission
- Use of melatonin before or during hospital admission
- Dialysis before admission
- History of diagnosed dementia
- Absence of arterial or central venous catheter

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint will be the differences in the maximal concentration of<br /><br>melatonin in critically ill elderly with or without delirium during ICU<br /><br>admission.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes will be the (differences in) melatonin secretion pattern,<br /><br>defined as the percentage peak melatonin concentration that are secreted<br /><br>between 23pm and 6am, in older persons with and without delirium for seven<br /><br>consecutive days.<br /><br>Also, we will study if sepsis, mechanical ventilation, renal failure or (nor)<br /><br>adrenergic stimulation influence melatonin secretion patterns in patients<br /><br>admitted to the ICU.</p><br>