Glycemic Index of Table Grape Varietals

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Milano grapes; Other: Table grapes; Other: Glucose beverage; Other: Grape juice

• Registration Number: NCT03248609
• Lead Sponsor: University of California, Davis

Brief Summary

Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.

Detailed Description

The study aims to investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals, compared to a standard amount of glucose. The study also aims to evaluate a new grape varietal, compared to other common table grapes, with regard to glycemic index and metabolic response related to inflammation.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-07-31
• Study First Submitted: 2017-08-09
• Study First Submitted QC: 2017-08-09
• Study First Posted: 2017-08-14
• Primary Completion: 2018-06-04
• Study Completion: 2018-06-04
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-30
• Last Update Posted: 2019-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Healthy men and women
• 21-75 years of age
• BMI range 20-35

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Exclusion Criteria

• adults unable to consent, individuals who are not yet adults (children), pregnant women, and prisoners.
• BMI of >35 or morbid obesity.
• Diagnosed type 1 or 2 diabetes, fasting blood glucose of >125 mg/dl, or reported use of medications or supplements known to affect glucose metabolism (insulin, sulfonylureas, metformin, glucosidase inhibitors, thiazolidinedione, insulin sensitizers, GLP-1 mimetics).
• Medications known to affect gastrointestinal motility (prokinetic agents such as reglan).
• Renal, liver, pancreatic or cardiovascular disease, uncontrolled hypertension of > 160/90, inflammatory bowel disease, disorders of esophageal and gastrointestinal motility, previous gastric resection or restriction procedures, autoimmune or immunologic disorders, anemia, breastfeeding women
• Food allergy to grapes, or inability to tolerate gluten (celiac disease).
• Poor venous access.
• Smoking, illicit drug use, consuming >7 alcoholic drinks per week.
• Weight gain or loss of > 5 kg within the prior 6 months.
• Unwillingness to adhere to study protocol.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Milano grapes	Milano grapes	Unique grape varietal to test glycemic response.
Table grapes	Table grapes	Common grape varietal to test glycemic response and compare to the glycemic response elicited by the Milano grape varietal.
Glucose beverage	Glucose beverage	Used to test the glycemic response with a standardized glucose beverage and compare to the glycemic response elicited by the Milano grape varietal.
Grape juice	Grape juice	Used to test the glycemic response without a complex food matrix and compare to the glycemic response elicited by the Milano grape varietal.

Primary Outcome Measures

Name	Time	Method
Glycemic Index	3 hours	The post-prandial glucose and insulin responses in healthy individuals to glucose containing foods or beverages.

Trial Locations

Locations (1)

University of California Davis (Academic Surge, Ragle Human Nutrition Research Facility); 🇺🇸 Davis, California, United States