Brain Abscesses in Transplant Recipients: a Multicentre Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Description of the current epidemiology of brain abscesses in transplant recipients
研究概览
简要总结
Allotransplantation is the process of transferring organ(s), tissue(s) or cell(s) from a healthy donor to a recipient. The two main applications of allotransplantation are solid organ transplantation and allogeneic hematopoietic stem cell transplantation. For several reasons, including the need to use immunosuppressive drugs after transplantation, recipients of allografts carry a high risk of infectious complications.
Central nervous system infections are dreadful complications of transplantation, which can be divided into brain abscesses, meningitis, and encephalitis. In particular, brain abscesses pose major diagnostic and therapeutic challenges to transplant physicians, and are frequently fatal in transplant recipients. As compared with immunocompetent patients, transplant recipients and other immunocompromised patients have an increased risk of brain abscesses due to opportunistic pathogens, including fungi, parasites, bacteria, and mycobacteria.
Determining the epidemiology of brain abscesses is critical to guide transplant teams regarding the diagnosis and management of brain abscesses in transplant recipients.
Because the incidence of brain abscesses is low after transplantation, transplant teams often have limited clinical experience in the management of these infections. Similarly, most publications focusing on post-transplant brain abscesses are either case reports, small case series, or review articles.
We therefore aim to conduct a multicentre retrospective study on the epidemiology, the characteristics, and the outcome of brain abscesses in transplant recipients in the era of new diagnostic tools and progress in prophylaxis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Transplant recipient (i.e., solid organ transplant recipient or allogeneic hematopoietic stem cell transplant recipient)
- •Radiological evidence of brain abscess(es) after transplantation
- •Brain abscess(es) classified as either proven, probable or possible (see definitions below)Diagnosis of brain abscess made between January 2010 and December 2021
排除标准
- •Opposition of the research
- •Patients under guardianship
结局指标
主要结局
Description of the current epidemiology of brain abscesses in transplant recipients
时间窗: 1 year after brain abscess diagnosis
Clinical and microbiological characteristics
次要结局
- Compare the clinical and microbiological characteristics of brain abscesses occurring early after transplantation (<M6) with those of brain abscesses occurring later after transplant (> M6)(1 year after brain abscess diagnosis)
- Assessment of the outcome of transplant recipients with brain abscesses(1 year after brain abscess diagnosis)
- Comparison of the clinical and microbiological characteristics of brain abscesses between solid organ transplant recipients and allogeneic hematopoietic stem cell transplant recipients(1 year after brain abscess diagnosis)
- Identification of clinical predictors associated with fungal brain abscesses versus brain abscesses due to non-fungal organisms(1 year after brain abscess diagnosis)
- Description of the current management of post-transplant brain abscesses in transplant recipients(1 year after brain abscess diagnosis)
- Identification of factors associated with patient survival in transplant recipients with brain abscesses(1 year after brain abscess diagnosis)