Treatment of acetaminophen toxicity
Not Applicable
- Conditions
- acetaminphen toxicity.Poisoning by nonopioid analgesics, antipyretics and antirheumatics (Salicylate)s
- Registration Number
- IRCT201112146948N2
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
The inclusion criteria: Patients with acetaminophen poisoning; ingesting the toxic acetaminophen dose (=7.5g); aged = 18 years old; coming to the hospital before 8 hours after acetaminophen ingestion.
The exclusion criteria: Less than 7.5g acetaminophen ingesting; aged under 18 years old; coming to the hospital after 8 hours after acetaminophen ingestion; vomiting two times after oral NAC was given; pregnant patients; those who had risk factors for hepatic toxicity (e.g. those who had hepatic cirrhosis; chronic ethanol ingestion; usage of substances that induce cytochrome P450 enzyme activity including rifampin; phenobarbital; isoniazid; phenytoin and carbamazepine).
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Anaphylactoid reactions. Timepoint: during NAC (N-acetylcysteine) infusion. Method of measurement: observation.
- Secondary Outcome Measures
Name Time Method