Comparison of Low and Normal Flow Anesthesia in Robotic Assisted Radical Prostatectomy

• Conditions: Low Flow Anesthesia; Normal Flow Anesthesia; Robotic Surgery
• Interventions: Procedure: robotic assisted radical prostatectomy

• Registration Number: NCT05517551
• Lead Sponsor: Ankara City Hospital Bilkent

Brief Summary

Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Since robot-assisted laparoscopic radical prostatectomy should be performed in the limited retroperitoneal area, insufflation of the abdomen with carbon dioxide (CO2) (pneumoperitoneum) and steep Trendelenburg position are required to provide better surgical vision.

Low-flow anesthesia warms and moistens the inhaled gases, creating a more physiological breathing atmosphere during anesthesia. In addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. Studies show that long-term minimal flow anesthesia is safe and advantageous for non-laparoscopic surgery.

The aim of this study is to compare low-flow (1L/min) with normal flow (3lt/min) desflurane anesthesia in terms of hemodynamic and respiratory parameters, inhalation agent consumption and soda lime consumption for robotic assisted laparoscopic radical prostatectomy surgery.

The secondary aim of the study is to compare the effects of low-flow and normal-flow anesthesia in the steep trendelenburg position (45°) used for robotically assisted laparoscopic radical prostatectomy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study Start: 2022-08
• Study First Submitted: 2022-08-23
• Study First Submitted QC: 2022-08-24
• Last Update Submitted: 2022-08-24
• Study First Posted: 2022-08-26
• Last Update Posted: 2022-08-26
• Primary Completion: 2022-09
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• ASA I-II risk group

Exclusion Criteria

• ASA III, IV, V,
• concomitant serious cardiac, respiratory, hepatic, renal disturbance,
• mental status disorder and hearing problem,
• anxiety and depression and/or other psychiatric disorders,
• patient's refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
normal flow anesthesia	robotic assisted radical prostatectomy	A fresh gas flow of 3 L/min will be applied continuously
low flow anesthesia	robotic assisted radical prostatectomy	A fresh gas flow of 3 L/min will be applied for the first 20 minutes after intubation , and then it will be reduced to 1 L/min.

Primary Outcome Measures

Name	Time	Method
inspiratory O₂ concentration	from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)	inspiratory O₂ concentration is measured from anesthesia machine monitor
partial oxygen pressure	from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)	PO2 from blood gas analysis

Secondary Outcome Measures

Name	Time	Method
desflurane consumption	perioperative	desflurane consumption at the end of anesthesia is measured from anesthesia machine monitor
changes in liver and kidney function tests from the preoperative values to 48 hours postoperative	during operation and 48 hours postoperative	to determine the changes in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine from the preoperative values to 48 hours postoperative

Trial Locations

Locations (1)

Ankara City Hospital; 🇹🇷 Ankara, Turkey