NL-OMON31744
Completed
Not Applicable
Emotional recognition, experience and empathy in persons with Moebius syndrome and persons with congenital bilateral facial paralysis. - Moebius project
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 50
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For the Moebius Participants and congenital bilateral facial paralysis the following inclusion criteria are required for Part I of the study:
- •\* Males and females between the ages of 18 and 65 years
- •\* Normal visual acuity or corrected to normal vision
- •\* The participants must be willing and able to participate in the measurements
- •\* The participants must have given written informed consent to be included in the study
- •\* Clinical diagnosis of Möbius Syndrome or congenital bilateral facial paralysis from a registered neurologist;For the Volunteer Control Participants for Part I, the following inclusion criteria are required:
- •\* Males and females between the ages of 18 and 65 years
- •\* Normal visual acuity or corrected to normal vision
- •\* The participants must be willing and able to participate in the measurements
- •\* The participants must have given written informed consent to be included in the study;We shall begin by scanning for Part II the first SIX fMRI suitable volunteers who apply. Depending on the results (see section 5\.3\) from this, this will determine how we will procede further with Part II.
Exclusion Criteria
- •For the Moebius Participants and congenital bilateral facial paralysis in Part I, the following exclusion criteria apply:
- •\* Those suffering from schizophrenia
- •\* Those suffering from a neurological disorder not related to Möbius e.g. epilepsy, Parkinson\*s disease, and Huntington\*s disease.;For the Moebius Participants and congenital bilateral facial paralysis in Part II of the study the following criteria apply:
- •\* Visual disorder that cannot be corrected through the use of corrective lenses to a level of 20\-40 in both eyes (we have MRI safe glasses for a very broad range of prescriptions)
- •\* Another significant CNS disorder (e.g. brain damage, epilepsy)
- •\* Pregnancy or suspected pregnancy
- •\* Those suffering from claustrophobia and/or a panic disorder
- •\* Subjects who do not fulfil the criteria for participating in an fMRI assessment (e.g. people who have metal implants (pacemaker, heart valves, vascular clips, eye\-implants or piercing))
- •\* Wishes not to be informed of brain abnormalities that may be noticed in the scans
- •\* If they are unable to suck through a straw;For the Control Participants in Part I the following exclusion criteria apply:
Outcomes
Primary Outcomes
Not specified
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