The analgesic effect of postoperative continuous intravenous Nefopam on acute postoperative pain after decompressive laminectomy and fusion in multi-level degenerative lumbar spinal stenosis: A prospective randomized, double-blind, placebo-controlled trial
Phase 4
- Conditions
- Pain after multilevel lumbar spine surgeryDegenerative lumbar spine, nefopam, post-operative pain, analgesia
- Registration Number
- TCTR20220615006
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
1. had been diagnosed with degenerative lumbar spinal stenosis undergoing operative by pedicular screw instrumentation more than three-level at Siriraj Hospital
2. Aged over 18 years
Exclusion Criteria
1. History of drug allergy to opioids, gabapentinoid, ketorolac or bupivacaine
2. Estimated glomerular filtration rate <30 ml/min
3. patients with history of epilepsy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24-hour morphine consumption 24 hours postoperative reported from PCA
- Secondary Outcome Measures
Name Time Method First time to first IV analgesic after operative report in minute after anesthesia,Mean pain score 12,24,36,48-hour postoperative Subjective examination,Nausea and vomiting 12,24,36,48-hour postoperative Subjective Examination,Tachycardia overed 100 times/min 12,24,36,48-hour postoperative blood pressure monitor,Side effects of opioids such as Hypotension, Respiratory depression 12,24,36,48-hour postoperative Subjective Examination,Morphine consumption from PCA 12,24,36,48 hour postoperative Report in the milligram from PCA record