The analgesic effect of postoperative continuous intravenous Nefopam on acute postoperative pain after decompressive laminectomy and fusion in multi-level spinal metastases: A prospective randomized, double-blind, placebo-controlled trial
Phase 4
- Conditions
- Pain after multilevel lumbar spine surgerySpinal metastasis, Nefopam, post-operative pain, analgesia
- Registration Number
- TCTR20220616001
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
1. had been diagnosed with Spinal metastases undergoing operative by pedicular screw instrumentation more than five-level at Siriraj Hospital
2. Aged over 18 years
Exclusion Criteria
1. History of drug allergy to opioids, gabapentinoid, ketorolac or bupivacaine
2. Estimated glomerular filtration rate <30 ml/min
3. Patients with history of epilepsy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method determine 24-hour morphine consumption 24 hrs. after operative PCA record
- Secondary Outcome Measures
Name Time Method First time to first IV analgesic after operative report in minute after anesthesia,Mean pain score on 12,24,36,48-hour after operative Visual Analog Scale,Nausea and vomiting on 12,24,36,48-hour postoperative Subjective Examination,Tachycardia 100 times/min on 12,24,36,48-hour postoperative Blood pressure monitor,Side effects of opioids such as Hypotension, Respiratory depression on 12,24,36,48-hour postoperative Blood pressure monitor,Morphine consumption from PCA (Report in the milligram of morphine consumption) on 12,24,36,48 hour postoperative PCA