The effect of amino acid administration on the reduction of muscle mass in patients undergoing gastrectomy
Phase 2
- Conditions
- Gastric cancer
- Registration Number
- JPRN-UMIN000027056
- Lead Sponsor
- Osaka medical college, General and Gastroenterological Surgery
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- Male
- Target Recruitment
- 150
Inclusion Criteria
Not provided
Exclusion Criteria
1)Patients with severe complications. 2)Requiring resection the other organs except the gallbladder. 3)Patients with infection in progress. 4)Emergency surgery. 5)Patients with uncontrolled diabetes. 6)Patients enrollment to the study is determined to be inappropriate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The ratio of skeletal muscle mass at 1 month after surgery to preoperative mass
- Secondary Outcome Measures
Name Time Method The ratio of body weight at 1 month after surgery to preoperative weight Postoperative complications Postoperative hospital stay Nutritional parameters (albumin, transthyretin, total protein, lymphocyte counts) Ingestion rate of leucine-rich amino acid Continuation rate of postoperative adjuvant chemotherapy
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways (e.g., mTOR, protein synthesis) are targeted by amino acid supplementation in gastric cancer gastrectomy patients?
How does preoperative amino acid administration compare to standard nutritional support in preserving skeletal muscle mass post-gastrectomy?
Which biomarkers (e.g., IL-6, TNF-α, myostatin) predict muscle preservation outcomes in JPRN-UMIN000027056 phase II gastric cancer trials?
What are the safety profiles and management strategies for amino acid-related adverse events in phase II gastrectomy studies?
How do amino acid interventions synergize with resistance training or other nutritional supplements in mitigating sarcopenia after gastric cancer surgery?