EUROPEAN STUDY OF THE CEREBELLAR MUTISM SYNDROME (CMS) IN CHILDREN WITH BRAIN TUMOURS OF THE POSTERIOR FOSSA
Recruiting
- Conditions
- Cerebellar Mutism Syndromeunable to speak after brain surgery1002921110009720
- Registration Number
- NL-OMON53502
- Lead Sponsor
- niversity of Copenhagen - Rigshospitalet - Department of Clinical Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
- Age <18 years at the date of first imaging showing this tumour
- Tumour in the cerebellum/4th ventricle/brainstem with intention to treat with
surgical resection or open biopsy. Second and further surgeries are also
included.
- Signed Informed consent from custodial parent(s) and/or patient
Exclusion Criteria
No informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To explore the relationship between different surgical methods for the removal<br /><br>of posterior fossa tumours, and relate these to<br /><br>the incidence and clinical course of the CMS (prospective observational study).<br /><br>Hypothesis: Methods that spare the dentate nuclei and their efferents and focus<br /><br>on minimally traumatic techniques lower the<br /><br>risk of developing the CMS by 50%, and lessen its severity and duration by 40%<br /><br>when compared to more invasive tumour<br /><br>removal methods. The risk of getting the CMS is greater after reoperation(<br /><br>s) when compared to primary surgery.</p><br>
- Secondary Outcome Measures
Name Time Method