Ketamine-propofol Versus Pethidine-propofol for Sedating Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- endoscopist satisfaction using 5 step scale (5= optimal condition; 1= poor condition)
研究概览
简要总结
The investigators aim to investigate the differences between ketamine propofol and pethidine propofol during ERCP in respect to endoscopist satisfaction.
详细描述
The investigators aim to investigate the differences between ketamine propofol and pethidine propofol during ERCP in respect to endoscopist satisfaction, amount of propofol consumption Any desaturation or apnea will be recorded when the oxygen saturation (SpO2) dropped to <90% , time for recovery ,post-operative nausea and vomiting, hallucinations and Ramsey sedation scores of all patients will be recorded perioperatively. The Aldrete score was used to measure recovery from anesthesia at 5 and 10 min after the procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •both gender
- •age between 18-70
排除标准
- •pregnant patients.
- •morbid obesity.
- •chronic obstructive pulmonary disease.
- •complicated airway.
- •American society of anesthesia (ASA) physical classification IV-V.
- •history of allergy or contraindications to the drugs used in the study
- •emergency need for ERCP.
- •those whose informed consent could not be signed.
- •those with possible complex ERCP.
研究组 & 干预措施
ketamine- propofol
IV Ketamine 1mg/kg + Propofol 1.2 mg/kg will be given for sedation.
干预措施: ketamine- propofol (Drug)
pethidine- propofol
1.1 mg x kg(-1) pethidine + 1.2 mg x kg(-1) propofol for sedation induction
干预措施: pethidine- propofol (Drug)
结局指标
主要结局
endoscopist satisfaction using 5 step scale (5= optimal condition; 1= poor condition)
时间窗: Immediately after procedure.
次要结局
未报告次要终点
研究者
khaled salah mohamed
lecturer of anaesthesia and ICU
Assiut University