Comparative Study Between Propofol-Ketamine Combination and Dexmedetomidine-Ketamine Combination for Sedation in Upper Gastrointestinal Endoscopy in Paediatric Patients.
Overview
- Phase
- Phase 4
- Intervention
- propofol-ketamine
- Conditions
- Upper Gastrointestinal Endoscopy
- Sponsor
- Ain Shams University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- length of stay in PACU
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to compere between Propofol-Ketamine combination and Dexmedetomidine-Ketamine combination for sedation in upper gastrointestinal endoscopy in paediatric patients.
Investigators
Akram Mohamed Mohamed Amer
Lecturer in Department of Anesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain-Shams University
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists ASA I-II patients aging 2-7 years.
Exclusion Criteria
- •known allergy to any of the study drugs, significant cardiovascular disease vomiting.
Arms & Interventions
Group PK
Propofol-Ketamine group: patients in this group will receive IV ketamine at a dose of 1mg.kg-1 in addition to IV propofol 1mg.kg-1 for induction with added doses of propofol 1mg.kg-1 when needed.
Intervention: propofol-ketamine
Group DK
Dexmedetomidine-Ketamine group: patients in this group will receive IV ketamine at a dose of 1mg.kg-1 in addition to IV dexmedetomidine 0.5 mcg.kg-1 for induction with additional doses of dexmedetomidine 0.5mcg.kg-1 when required
Intervention: Dexmedetomidine-ketamine
Outcomes
Primary Outcomes
length of stay in PACU
Time Frame: three months