Comparison Between Dexmedetomidine-Propofol and Ketamine-Propofol Administration for Sedation of CT Guided Bone Biopsy: A Randomized Controlled Trial
Overview
- Phase
- Phase 4
- Intervention
- Dexmedetomidine-propofol
- Conditions
- Sedation
- Sponsor
- National Cancer Institute, Egypt
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Heart rate
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study aims to compare the effectiveness and safety of a dexmedetomidine-propofol combination and a ketamine-Propofol combination for sedation of CT guided bone biopsy.
Detailed Description
Assessment of boney lesions is an common activity in the care of cancer patients. CT guided Percutaneous needle biopsies have a low complication rate. usually, this procedure is done under sedation. Propofol is a non-barbiturate hypnotic and sedative. It facilitates gamma-aminobutyric acid mediated inhibitory neurotransmission. It's known to have anti-emetic, antipruritic, anticonvulsant and amnestic effects. Despite being effective and potent, Propofol's main disadvantages is its dose-dependent hypotension and respiratory depression .Ketamine is a phencyclidine derivative which acts as a N-methyl-D-aspartate (NMDA) receptor antagonist. It is a dissociative anesthetic and provides some analgesia. It maintains airway reflexes and spontaneous respiration. Combining Propofol and ketamine preserves the sedative and analgesic efficacy while reducing their adverse effects. Dexmedetomidine is a highly selective α2-agonist. It is eight times more specific compared with clonidine. It has a perioperative anxiolytic, sedative properties as well as some analgesic properties .Dexmedetomidine is usually used for mild to moderate sedation and Propofol could be added to deepen the level of sedation
Investigators
Eligibility Criteria
Inclusion Criteria
- •Stated willingness to comply with all study procedures and availability for the duration of the study .
- •Age between 18 to 60 years old
- •American Society of Anesthesiologists (ASA) physical I-III
- •Scheduled for CT guided bone biopsy with sedation.
Exclusion Criteria
- •Severe heart, lung, and liver disease
- •kidney failure
- •Bleeding diathesis Allergy to drugs to be used
Arms & Interventions
Dexmedetomidine-propofol
Dexmedetomidine-propofol bolus will be administered then Dexmedetomidine-propofol infusion continued during the procedure
Intervention: Dexmedetomidine-propofol
ketamine-propofol
ketamine-propofol bolus will be administered then Dexmedetomidine-propofol infusion continued during the procedure
Intervention: Ketamine-Propofol
Outcomes
Primary Outcomes
Heart rate
Time Frame: before administration (baseline), every 10 minutes during the procedure, every 15 minutes for one hour postoperatively
change in heart rate
Secondary Outcomes
- Mean arterial blood pressure(before administration (baseline), every 10 minutes during the procedure, every 15 minutes for one hour postoperatively)
- Visual analogue scale (VAS) score for pain(every 15 minutes for one hour postoperatively)
- recovery time(immediately postoperative)