Opioidergic Mechanisms of Motivated Endogenous Pain Modulatio
- Conditions
- Pain Processing
- Registration Number
- DRKS00033920
- Lead Sponsor
- Institut für systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 49
•Healthy, adult participants
•German at native speaker level
•Right-handedness
•Acute or chronic pain (including sore muscles)
•Presence of acute or chronic somatic or psychiatric illnesses (based on self-report)
•MR-specific exclusion criteria (e.g. claustrophobia, pacemaker, non-MR-compatible metallic foreign bodies)
•Participation in studies with medication, or regular use of medication (except thyroid, allergy medication, occasional use of painkillers, contraceptives) within the last 2 months before start of the examination
•Taking painkillers within the last 24 hours before the start of the examination
•Fear of needles/blood samples
•Pregnancy or breastfeeding
•Acute skin disease or injury in the areas to be stimulated
•Acute illness or symptoms of the respiratory tract (e.g. exercise-induced asthma)
•Past or existing physical opioid dependence
•Cardiovascular disease (e.g. angina pectoris)
•Disease of the nervous system
•Disease of the immune system
•Disease of the gastrointestinal tract
•Ingestion of cardiotoxic drugs/substances (e.g. cocaine,
metamphetamine, cyclic antidepressants, calcium antagonists, beta blockers, digoxin)
•Metallic hardware in the body (e.g. IUDs, stents, ferromagnetic bone screws, etc.)
•Electromagnetic devices (e.g. pacemakers)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of this study is to investigate whether the motivation to engage in an action in order to receive a monetary reward leads to pain reduction mediated by endogenous opioids.
- Secondary Outcome Measures
Name Time Method The secondary aim is the examination of neuronal mechanisms of pain modulation by motivation