The elucidation for the modulation of endogenous pain inhibitory mechanism by drugs for the treatment of neuropathic pai
- Conditions
- healthy volunteers
- Registration Number
- JPRN-UMIN000053700
- Lead Sponsor
- Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Not provided
the inability to give informed consent, under 18 years old, patients with a history of hypersensitivity to any of these ingredients, which is a contraindication to the administration of drugs of pregabalin, myrogabalin, duloxetine, amitriptyline, or vaccinia virus inoculated rabbit inflammatory skin extract, patients on monoamine oxidase (MAO) inhibitors or within 2 weeks of discontinuation of MAO inhibitors, patients with severe hepatic dysfunction, angle-closure glaucoma, early recovery from myocardial infarction, or urinary retention (prostate disease, etc.), requiring caution in administration, acute intoxication with alcohol, sleeping pills, analgesics, opioid analgesics or psychotropic drugs, within 1 week after receiving or discontinuing nalmefene hydrochloride hydrate, epilepsy not adequately controlled by treatment, renal dysfunction, severe congestive heart failure, elderly patients, history of angioedema, tendency or history of drug dependence, psychiatric disorders, pregnant women, and nursing mothers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The evaluation of CPM effect before and after oral medication of the drugs for neuropathic pain. CPM effect is evaluated by pressure pain threshold (PPT) before and during conditioning stimulus.
- Secondary Outcome Measures
Name Time Method the modulation of QST (the Thermal Pain Illusion(TPI), Temporal Summation(TS), Offset Analgesia(OA) etc) and the effect of background (for example, psychology test including SDS, STAI, PCS etc), and the stress evaluated by catecholamine concentrations in plasma, urine and sweat.