Prevention of acute renal failure, molecular mechanism of dietary preconditioning in human.

Not Applicable

• Conditions: N17; Acute renal failure

• Registration Number: DRKS00007704
• Lead Sponsor: niversität zu Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10-14
• Study Completion: 2019-05-25
• Results First Posted: 2020-04-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Competent persons > 18 years of age
2. Planned living kidney donation
3. Written informed consent under legal competence
4. BMI > 18.5 kg/m²

Exclusion Criteria

1. Competent persons < 18 years of age
2. BMI < 18.5 kg/m²

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analysis of following outcomes from biopsy of donor's kidney:<br>- Transkriptom<br>- Lipidom<br>- Metabolom<br>- Epigenom<br>- Proteom<br>- Phosphoproteom

Secondary Outcome Measures

Name	Time	Method
- Change in NGAL (µg/L) in urine (prior to surgery in donor and recipient; 6h, 12h and 24h after surgery only in recipient)<br>- Cystatin C (prior to surgery in recipient; daily sampling until the 7th day after surgery only in recipient)<br>- Occurrence of acute renal failure in accordance with KDIGI I, II, III<br>- maximum serum creatinine during hospital stay after surgery