Does conservative fluid therapy compared to usual care change the outcomes in critically ill patients with acute kidney injury.

Not Applicable

• Conditions: acute kidney injury; critical illness; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12622000030774
• Lead Sponsor: Metro South Hospital and Health Service

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-01-14
• Last Update Posted: 24 January 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 293

Inclusion Criteria

•Adult patient, age >=18
•Admitted to the intensive care unit for less than 72 hours
•Acute kidney injury defined by any of the following:
o>= 1.5 times baseline creatinine (assume normal if baseline unknown)
OR
o>= 27 umol/L (0.3mg/dL) absolute increase in creatinine
OR
o< 0.5ml/kg/hr urine output for at least 6 hours
•Deemed to be adequately fluid resuscitated as per treating clinician’s assessment
•Patient to remain in ICU until the day after tomorrow

Exclusion Criteria

•Maintenance fluid deemed necessary (e.g. for diabetic ketoacidosis or severe burns)
•Requirement for RRT, such as dialysable toxin
•Commencement of RRT for AKI is likely in the next 6 hours
•Chronic haemodialysis or peritoneal dialysis
•Acute renal transplant
•Presence or strong suspicion of post-renal obstruction
•Severe hyponatremia (Na <125mmol/L) or hypernatremia (Na >155mmol/L)
•Need for extracorporeal membrane oxygenation
•Previous enrolment in this study
•Pregnant or lactating
•Patients who are not to receive full active treatment

Study & Design

• Study Type: Interventional
• Study Design: Not specified