acetyl cysteine (NAC) augmentation in Obsessive-Compulsive Disorder (OCD): A 24-week, randomized, double blind placebo controlled trial

Phase 3

Completed

Conditions: Obsessive-Compulsive Disorder
Mental Health - Other mental health disorders

Registration Number: ACTRN12616000847415

Lead Sponsor: The University of Melbourne

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 98

Inclusion Criteria

Primary diagnosis of OCD as per the Structured Interview Guide for the DSM-5 (SCID)
Adults between the age of 18-75 who have the desire and capacity to consent to the study and follow its procedures.

Minimum score of 16 on the Y-BOCS at time of entry into the study, but no greater than 31.

Currently taking medication for their OCD which has been at a stable dose for the past 8-weeks.

Stable psychological treatment (if employing) for minimum eight weeks (an 8-week wash-out period will be required if participants have just completed an intensive in-patient CBT program for their OCD).

Exclusion Criteria

*Bipolar disorder
*Psychotic disorders
*Primary diagnosis of Obsessive-compulsive spectrum disorders including hoarding, body dysmorphic disorder, trichotillomania (secondary diagnosis permitted)
*Severe depression (as defined by HAM-D score equal to or greater than 24
*Alcohol/substance abuse
*Y-BOCS score equal to or greater than 32
*Treatment resistant OCD (3 or more trials of first line medications for their OCD at therapeutic doses for minimum of 12-weeks each, at least one augmentation strategy, for example, anti psychotic medication as well as exposure response prevention therapy minimum 20 hours)
*Medications with known or suspected negative interactions with NAC (activated charcoal, nitro glycerine, insulin replacement therapies, Aralen, anti-coagulant medications excluding aspirin and NSAIDS)