Comparative Evaluation of the Effect of a Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 42
- 主要终点
- Post operative pain assessed with the Numerical Rating Pain Scale
研究概览
简要总结
the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and NSAID(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy patient (ASA I or II).
- •Mandibular Posterior teeth with:
- •Preoperative sharp pain.
- •Absence of widening in the periodontal ligament (PDL).
- •Vital response of pulp tissue to cold pulp tester (ethyl chloride spray).
排除标准
- •Patients allergic to anesthetics, piroxicam (any other NSAIDs) or dexamethasone (other corticosteroids).
- •Pregnant or nursing females.
- •Patients having significant systemic disorder (ASA III or IV).
- •Hemostatic disorders or anti-coagulant therapy during the last month.
- •Consumption of opioid or non-opioid analgesics or corticosteroids during the last 12 hrs before treatment.
- •Retreatment cases.
研究组 & 干预措施
dexamethasone
Pretreatment intraligamentary injection of 0.4 mL of 8 mg/2 mL dexamethasone (Dexamethasone, AMRIYA pharmaceutical, Egypt)
干预措施: Dexamethasone sodium phosphate (Drug)
piroxicam
Pretreatment intraligamentary injection of 0.4 mL of 20 mg mL-1 piroxicam (Feldene, Pfizer, Egypt)
干预措施: Piroxicam Injectable Solution (Drug)
Mepivacaine HCL
Pretreatment Intraligamentary injection of 0.4 mL of Mepivacaine HCl 36 mg /1.8 ml + Levonordefrin HCl 0.108 mg/ 1.8 ml (Mepecaine - L, Alexandria Co.-Egypt)
干预措施: Mepivacaine HCL (Drug)
结局指标
主要结局
Post operative pain assessed with the Numerical Rating Pain Scale
时间窗: up to 48 hours after root canal treatment (At 4,6,12,24 and 48 hours after root canal treatment ).
Intensity of pain after endodontic treatment is recorded by the patient using a numerical rating scale(where 0= no pain ,1-3 =mild pain ,4-6= moderate pain and 7-9= severe pain )
次要结局
- number of analgesics taken by the patient(Until 48 hours after endodontic treatment.)
研究者
Safwa Essam Mohammed Ahmed Abd el-glil
resident at faculty of dentistry cairo university
Cairo University