Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study
- Conditions
- Dysfunctional BreathingRespiratory AlkalosisHyperventilationChronic Idiopathic Hyperventilation
- Registration Number
- NCT01575665
- Lead Sponsor
- University of Aarhus
- Brief Summary
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively. The investigators hypothesised that by periodically inducing normocapnia over several weeks, it would be possible to raise the normal resting level/set point of CO2 and achieve a reduction of symptoms.
Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing mask. The mask was used to induce normocapnia in these chronically hypocapnic patients.
Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline and once each week at least three hours after mask use, as well as spirometric values, breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire (NQ),.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
Chronic idiopathic hyperventilation, i.e.:
- PCO2 level below 4.7 kPa AND
- SBE value more negative than -1.0
- Oxygen saturation of 95% or lower at rest
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Blood gas and acid/base status Once every week in the treatment period of four weeks pH, PCO2, PO2, Standard Base Excess
- Secondary Outcome Measures
Name Time Method Breath Hold Tolerance once a week Spirometric values once a week FEV1, FVC
Hyperventilation symptoms once a week Nijmegen Questionnaire
Trial Locations
- Locations (1)
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Aarhus University Hospital🇩🇰Aarhus, Denmark