The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy
- Conditions
- Nonalcoholic Fatty Liver Disease After Pancreaticoduodenectomy
- Registration Number
- NCT07182136
- Lead Sponsor
- Wei-Hsun Lu
- Brief Summary
We will use simple summaries, educational handouts, and discussions with doctors and nurses to explain this study. The study looks at patients with early-stage pancreatic cancer who undergo pancreaticoduodenectomy (Whipple surgery). We found that some patients develop fatty liver (non-alcoholic fatty liver disease, NAFLD) within six months after surgery, which can affect nutrition, blood sugar control, and long-term survival.
To help patients and families understand, we will:
1. Provide clear written information sheets about the purpose of the study and its findings.
2. Use diagrams or plain-language explanations of terms like "pancreatic exocrine function" and "fatty liver."
3. Share results with healthcare providers so they can guide patients in nutrition, enzyme replacement, diabetes monitoring, and follow-up care.
4. Offer contact information for the research team to answer questions.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Adults with stage I-II pancreatic ductal adenocarcinoma.
- Underwent curative-intent pancreaticoduodenectomy (conventional or pylorus-preserving).
- Surgery between January 2015 and May 2023.
- Complete clinical and imaging data available.
- Survived at least 6 months postoperatively.
- Preoperative hepatic steatosis
- Incomplete clinical or imaging data
- Death within 6 months after surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of postoperative nonalcoholic fatty liver disease (NAFLD) 6 months after pancreaticoduodenectomy
- Secondary Outcome Measures
Name Time Method