Genetic Basis of Pacing-induced Cardiomyopathy

Recruiting

• Conditions: Cardiomyopathies; Pacemaker, Artificial
• Interventions: Other: Saliva sample

• Registration Number: NCT03317964
• Lead Sponsor: The Guthrie Clinic

Brief Summary

The purpose of this study is to collect a saliva sample from patients with a pacemaker to study genes involved in cardiomyopathy, a condition where the heart muscle is abnormal.

Detailed Description

DNA will be extracted from the saliva to test for changes in genes related to cardiomyopathy.

Study Timeline

• Study Start: 2017-10-16
• Study First Submitted: 2017-10-16
• Study First Submitted QC: 2017-10-18
• Study First Posted: 2017-10-23
• Last Update Submitted: 2025-01-31
• Status Verified: 2025-02
• Last Update Posted: 2025-02-03
• Primary Completion: 2026-12-01
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

• Patients who have been assessed for cardiomyopathy

Exclusion Criteria

• Patients who do not have adequate follow up care to determine if they do or do not have cardiomyopathy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Saliva - no cardiomyopathy	Saliva sample	Saliva sample for genetic testing from subjects who do not have cariomyopathy
Saliva - cardiomyopathy	Saliva sample	Saliva sample for genetic testing from subjects who developed cardiomyopathy

Primary Outcome Measures

Name	Time	Method
Number of participants with genotype frequency	through study completion, an average of 1 year	Number of participants with genotype frequency based on genetic testing of saliva samples

Trial Locations

Locations (1)

Robert Packer Hospital; 🇺🇸 Sayre, Pennsylvania, United States