Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants
- Conditions
- Cardiomyopathy
- Registration Number
- NCT03754101
- Lead Sponsor
- Tongji Hospital
- Brief Summary
Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 4000
· Patients diagnosed as cardiomyopathy according to the definition of American Heart Association
- Uncontrolled hypertension significant valvular disease
- Mild ischemic heart disease
- Significant systemic infection
- Thyroid-induced cardiomyopathy
- Excessive alcohol consumption
- Precious cancer treatment including irradiation
- Refusal to participate in the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Heart transplantation confirmed by medical record up to 24 months Heart transplantation within 24 months
Cardiovascular death confirmed by death comfirmation or interview with the relatives up to 24 months Death from cardiovascular causes and any unknown death unless there was another certain cause
- Secondary Outcome Measures
Name Time Method All cause death confirmed by death comfirmation or interview with the relatives up to 24 months Any death at hospital or after discharge
Heart failure recurring confirmed by medical record up to 24 months Recurrence of heart failure at hospital or after discharge
Trial Locations
- Locations (1)
Tongji Hospital
🇨🇳Wuhan, Hubei, China