Association of Plasma Transfusions and Invasive Fungal Infection

Recruiting

• Conditions: Neonatal Infection; Plasma Administration; Invasive Fungal Infection
• Interventions: Drug: non-plasma transfusions; Drug: plasma transfusions

• Registration Number: NCT03149562
• Lead Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Brief Summary

Although lacking strong evidences, plasma transfusions are commonly used in critically ill neonates. To date, the relationships between plasma transfusions and nosocomial infection remain controversial and no study has reported the relationships between plasma transfusion and invasive fungal infection (IFI)

Detailed Description

Our aim is to explore the association between plasma transfusions and IFI in critically ill neonates

Study Timeline

• Study Start: 2011-01-01
• Study First Submitted: 2017-05-03
• Study First Submitted QC: 2017-05-09
• Study First Posted: 2017-05-11
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-23
• Last Update Posted: 2022-10-25
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• all critically ill neonates admitted in hospital

Exclusion Criteria

• severe congenital abnormality;
• died within 24 hours or left neonatal intensive care unit within 24 hours according to their parents' decisions;
• parents' decision not to participate.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-plasma transfusions	non-plasma transfusions	The critical ill neonates without plasma transfusions
plasma transfusions	plasma transfusions	The critical ill neonates with plasma transfusions

Primary Outcome Measures

Name	Time	Method
the rate of invasive fungal infection	100 days	the rate of invasive fungal infection in plasma transfusions group

Trial Locations

Locations (1)

Department of Pediatrics, Daping Hospital, Third Military Medical University; 🇨🇳 Chongqing, Chongqing, China