Psychiatric Multi-omics and Neuroimaging Project Database
概览
- 阶段
- 不适用
- 干预措施
- Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
- 疾病 / 适应症
- Mental Disorders
- 发起方
- mingjun Zhong
- 入组人数
- 1899
- 试验地点
- 1
- 主要终点
- cortical morphology
- 状态
- 招募中
- 最后更新
- 上个月
概览
简要总结
This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three. Patients with mental disorders who have been recruited will take their medication regularly for 1 year and participate in baseline and follow-up assessments.
详细描述
The study seeks to identify possible biological markers of schizophrenia and the effects of gene-environment interactions on brain structural and functional networks. So we can help doctors and scientific researchers better understand the neuropathological basis of schizophrenia.
研究者
mingjun Zhong
Principal Investigator
Second Xiangya Hospital of Central South University
入排标准
入选标准
- •Age: 13-35 years old(Patients with healthy siblings can be extended to 14-35 years of age)
- •Course of disease: \<24 months
- •Priority is given to patients who have never taken medicine or duration of drug use \< 2 weeks
- •No nuclear magnetic contraindications.
排除标准
- •Family history of psychotic disorders, history of psychoactive substances abuse, alcohol dependence, or nicotine dependence
- •Have a major physical disease or infectious disease
- •History of coma and serious neurological disease 4.MRI contraindications.
研究组 & 干预措施
PMNP-Healthy Norms
Healthy Norms
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
PMNP-Subclinical high-risk
Subclinical high-risk
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
PMNP-Schizophrenia and Psychosis
Schizophrenia and Psychosis patient
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
PMNP-MDD
major depressive disorder patient
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
PMNP-ASD
autism spectrum disorder patient
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
PMNP-BD
bipolar disorder patient
干预措施: Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
结局指标
主要结局
cortical morphology
时间窗: 40 minutes
Data were obtained using magnetic resonance scans
target gene charaacteristics
时间窗: 1 day
10ml peripheral blood was extracted for gene analysis
scale scores
时间窗: 90 minutes.
The score of each dimension and the total score were calculated according to the scale.The scale includes three dimensions: negative symptom, positive symptom and general psychopathology, and the score range of each dimension is different. The total score ranges from 30 to 210, with higher scores indicating worse results.