A Combined Psycho-pharmacological and Brain Imaging Study of Human Sexuality
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 40
- 主要终点
- Brain Imaging data of DRD2 receptor occupancy during watching a sex videotape and neutral videotape
研究概览
简要总结
The current study combines a molecular genetic perspective, self report and brain imaging to the study of human sexuality in control subjects and individuals from a sexual disorder clinic. The investigators hypothesize that the variability in components of the brain dopaminergic system expressed in the mesolimbic reward system can explain variability in human sexuality, especially in desire and pleasure associated with sex.
详细描述
We intend to combine molecular genetics of the dopamine receptors (D2, D3 D4 and D5) and brain imaging using 11 C Raclopride in Positron Emission Tomography (PET). 11 C Raclopride is a ligand which binds to the dopamine receptor D2 and can measure dopamine release during pleasure or anticipatory reward associated with sex. The current proposal will measure changes in DRD2 receptor occupancy using 11 C Raclopride following explicit visual sexual desire cues in healthy control subjects and individuals who suffer from sexual dysfunction. This is in order to determine how individual genotypes modulate dopamine release in vivo in the human brain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers and patients
- •Age 21-65
- •Male or female
排除标准
- •Psychiatric diagnosis/psychosis
- •Neurological damage associated with loss of consciousness
- •Infectious disease HIV
- •Hyperactivity treated with ritalin
- •Pregnant women
- •Under age
结局指标
主要结局
Brain Imaging data of DRD2 receptor occupancy during watching a sex videotape and neutral videotape
时间窗: 2 Brain imaging sessions a week apart
次要结局
- Questionnaire ratings of human sexuality, pleasure, and anticipatory reward(Taken during brain scans)