Clotting Factor Replacement Therapy And Bone Mineral Density In Childre
Not Applicable
- Conditions
- Health Condition 1: D66- Hereditary factor VIII deficiency
- Registration Number
- CTRI/2023/12/060585
- Lead Sponsor
- Guru Gobind Singh Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All males fulfilling the following criteria:
Severe hemophilia[Factor VIII Levels <1% of normal at diagnosis]
Exclusion Criteria
1.Evidence of chronic liver,lung or renal disease.
2.Evidence of morbid obesity.
3.Evidence of prolonged neurological diseases and cerebral palsy.
4.Viral markers positive[HIV,HBV,HCV]
5.Evidence of hyperparathyroidism,thyrotoxicosis,cushing syndrome.
6.On steroid or antiepileptic medication.
7.Evidence of vitamin D deficiency.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BMD Z score pre and post type of therapyTimepoint: BMD Z score pre and post type of therapy before and after 6 months
- Secondary Outcome Measures
Name Time Method Annual bleed rate. <br/ ><br>Target joint bleed rate. <br/ ><br>Annual joint bleed point.Timepoint: Pre and post therapy after 6 months.