Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- consumption of morphine over the first 48 hours postoperative.
研究概览
简要总结
The indications liver cancer surgery currently booming due to the increase in surgical techniques and instruments for a more secure resection of liver tissue with a significant reduction in bleeding or surgical complications. This allowed to expand surgical indications in the most fragile patients so assuming optimized anesthetic care.
So far, the technique of analgesia reference to this surgery remains administration of morphine analgesia via a device controlled by the patient (PCA) for epidural analgesia is against-indicated because of induced bleeding disorders by surgery.
Rafi then McDonnell in 2007 have described a new technique of loco regional anesthesia, the abdomen of the Transversus Abdominis Plane (TAP) nerve block(TAP), which allows selective anesthesia of the abdominal wall. But parietal pain related muscular and nervous sagging surgical approach represent a significant share of post operative pain.
This study proposes an evaluation of the abdomen transverse blocks in hepatectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hepatectomy or segmentectomy
排除标准
- •Sepsis uncontrolled current
- •Overdose in anticoagulant during general anesthesia
- •Thrombocytopenia <50 g / dl
- •Severe renal impairment: Cockcroft <30 ml / min
- •history of ventricular arrhythmia serious unexplained .*
- •Allergy to local anesthetics of the amide
- •Contraindication to remifentanil and morphine
- •Hypovolemia
研究组 & 干预措施
ropivacaïne chlorhydrate monohydrate
干预措施: RopivacaIne chlorhydrate (Drug)
placebo
干预措施: Placebo (Drug)
结局指标
主要结局
consumption of morphine over the first 48 hours postoperative.
时间窗: at 48 hours postoperative
次要结局
- pharmacokinetic of ropivacaine (plasma concentrations)(1, 2, 3, 6, 10, 24, 36, 48 hours post-dose)