Evaluate the Evolution of Body and Scalp Skin Discomfort in Patients With Hereditary Ichthyosis After Wraps (EnvelopIchtyose)
- Conditions
- Ichthyosis Inherited
- Interventions
- Procedure: Cutaneous wraps
- Registration Number
- NCT05979506
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
Ichthyosis is a group of rare and chronic genetic diseases beginning at birth, in which the patient's skin is covered with scales of variable appearance and severity. This disease is disabling. The treatment is symptomatic and is based on the daily application of moisturizing creams with a high lipid content. Nevertheless, the effectiveness of these treatments is limited and are considered very painful by the patients. Wraps are local treatments carried out by specialized nurses and which consist in, following a therapeutic bath, applying a large quantity of cream to the whole body, followed by an occlusion. This type of care is simple to perform, but requires nursing expertise, to date, it is not carried out in standard practice in France, which is why the investigateur wish to evaluate the effect of wraps on different parameters reflecting the skin condition in the short and medium term.
- Detailed Description
Ichthyosis is a group of rare and chronic genetic diseases beginning at birth, in which the patient's skin is covered with scales of variable appearance and severity. There are 2 distinct typical profiles: patients with thick scales without erythroderma and patients with finer scales on an erythrodermic background. This disease is disabling, in particular due to sensations of pruritus, skin pain and the possible presence of associated extra-cutaneous abnormalities. The treatment is symptomatic and is based on the daily application of moisturizing creams with a high lipid content for better effectiveness, keratolytic creams, and for severe forms, oral retinoids may be necessary. The creams improve the condition of the skin and reduce the sensations of skin discomfort, pain and pruritus, nevertheless, the effectiveness of these treatments is limited and are considered very painful by the patients.
Wraps are local treatments carried out by specialized nurses and which consist in, following a therapeutic bath, applying a large quantity of cream to the whole body, followed by an occlusion. The type of cream is adapted to the area of application: thus, an emollient cream is used for the body; a cream enriched with keratolytic active ingredients is used for the feet in the event of hyperkeratosis, and an emollient cream possibly enriched with keratolytic active ingredients is used for the scalp, followed by an exposure time under a steam helmet to remove scales. This type of care is simple to perform, but requires nursing expertise, to date, it is not carried out in standard practice in France, except in the centers of Toulouse, Bordeaux and Necker and at the thermal cure of Avène-les-Bains. However, the interest of such a treatment has never been evaluated independently, which is why in this study the investigators want to evaluate the effect of carrying out a daily treatment over 3 consecutive days, on different parameters reflecting the skin condition in the short and medium term
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 34
- Patient with hereditary ichthyosis regardless of the clinical form
- Patient with a scaling or erythema score > 6/16
- Patient with a skin discomfort score > 3/10
- Patient having given written, free and informed consent
- Patient affiliated to a social security scheme
- Patient with a skin disease other than ichthyosis
- Patient having modified his treatments for ichthyosis in the month preceding inclusion
- Patient with known intolerance or allergy to one of the topicals used in the study
- Patient unable to complete the study questionnaires
- Patient under a protection regime
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Wraps (body and feet) as well as scalp care Cutaneous wraps The skin care consisting of wraps (body and feet) and scalp care, will be carried out consecutively over 3 days, in the hospital (outpatient or in day/traditional hospitalization).
- Primary Outcome Measures
Name Time Method Skin discomfort Analogue Visual Scale (AVS) day 11 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the entire body, measured with the AVS scale (0-10) of cutaneous discomfort between baseline and 11 days after treatment
- Secondary Outcome Measures
Name Time Method Reduction of skin discomfort - day 4 day 4 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the entire body, measured with the Analogue Visual Scale (AVS) (0-10) of cutaneous discomfort between baseline and day 4
sweating - day 4 day 4 Variation of sweating assessed by the Analogue Visual Scale (0-10)
Variation of erythema and scales severity - VIIS day 4 Variation of erythema and scales severity judged by :
- Their intensity, measured with the Visual Index for Ichthyosis Severity (VIIS)Variation of erythema and scales severity day 4 Variation of erythema and scales severity judged by :
-Their extent, measured with the scores A and B of the Specific Clinical Ichthyosis ScoreReduction of skin discomfort - day 30 day 30 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the entire body, measured with the Analogue Visual Scale (AVS) (0-10) of cutaneous discomfort between baseline and day 30
Cutaneous pain - day 4 day 4 Variation of pain assessed by the Analogue Visual Scale (0-10) of skin pain
sweating - day 11 day 11 Variation of sweating assessed by the Analogue Visual Scale scale (0-10)
Cutaneous pain - day 30 day 30 Variation of pain assessed by the Analogue Visual Scale (0-10) of skin pain
sweating - day 30 day 30 Variation of sweating assessed by the Analogue Visual Scale (0-10)
Feet and scalp discomfort - day 4 day 4 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the feet and scalp, measured with the Analogue Visual Scale (0-10) of cutaneous discomfort
Feet and scalp discomfort - day 11 day 11 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the feet and scalp, measured with the Analogue Visual Scale (0-10) of cutaneous discomfort
pruritus - day 11 day 11 Variation of pruritus assessed by the Analogue Visual scale (0-10)
pruritus - day 30 day 30 Variation of pruritus assessed by the Analogue Visual Scale scale (0-10)
pruritus - day 4 day 4 Variation of pruritus assessed by the Analogue Visual Scale (0-10)
Cutaneous pain - day 11 day 11 Variation of pain assessed by the Analogue Visual scale (0-10) of skin pain
Feet and scalp discomfort - day 30 day 30 Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the feet and scalp, measured with the Analogue Visual Scale (0-10) of cutaneous discomfort
32-item Ichthyosis Quality of Life questionnaire (IQoL-32) 30 days after treatment Variation of patient's quality of life, measured by the ichthyosis specific quality of life questionnaire (IQoL-32)
Trial Locations
- Locations (1)
Toulouse University hospital
🇫🇷Toulouse, France