Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- AMH Levels in Women With PCOS
研究概览
简要总结
The purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin D treatment in women with PCOS.
详细描述
Seventy-nine women with (n=22) or without (control; n=57) PCOS who were diagnosed with vitamin D deficiency were enrolled. Sixty-three women were treated with oral vit D3 for 8 weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10 controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were used as appropriate.
Main outcome measure: Changes in AMH concentrations following vit D3 replacement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 48 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Vitamin D deficient premenopausal women
排除标准
- •Pregnant women
- •Women during their postpartum period
- •Breastfeeding women
- •Women taking any kind of exogenous hormones
- •Women receiving any form of oral vitamin D replacement
研究组 & 干预措施
Vitamin D treatment
Sixty-three vitamin D deficient women (16 with PCOS and 47 without PCOS) were supplemented with 50.000 IU of oral vitamin D3, once weekly for 8 weeks. Serum 25-hydroxyvitamin D (25OH-D), sRAGE and AMH levels were checked before and after treatment.
干预措施: Vitamin D3 (Drug)
结局指标
主要结局
AMH Levels in Women With PCOS
时间窗: 8 weeks after completing vitamin D treatment
AMH measured by serum analysis
次要结局
未报告次要终点