Pleurodesis Using Hypertonic Glucose
Phase 2
Not yet recruiting
- Conditions
- Air Leak From Lung
- Interventions
- Drug: Dextrose 50Other: Standard of Care - No Dextrose 50
- Registration Number
- NCT06293885
- Lead Sponsor
- Lawson Health Research Institute
- Brief Summary
Air leaks from unhealed lung tissue following lung resection for benign or malignant lesions are one of the most common complications following thoracic surgery, occurring after 10% of major lung resections. The purpose of this study is to investigate the efficacy of intrapleural administration of Dextrose 50% to resolve air leaks after pulmonary resection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Adult patients undergoing scheduled pulmonary lobar or sublobar resection for cancer
- Presence of air leak on postoperative day 1 of at least 100 mL/min, as documented on the digital drainage system
Exclusion Criteria
- None
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description D50 Dextrose 50 A solution of 50% glucose will be injected into the pleural space on the first and possibly the second day after surgery. The injection will be administered through the chest tube, which is already in place. Standard of care Standard of Care - No Dextrose 50 monitor air leak, if the air leak continues on post-operative day #5, a talc pleurodesis may be given.
- Primary Outcome Measures
Name Time Method Prolonged Air Leak 5 days postoperatively Prolonged Air Leak
- Secondary Outcome Measures
Name Time Method Home with Chest Tube immediately after the surgery Home with Chest Tube (y/n)
Duration of Chest Tubes immediately after the surgery Duration of Chest Tubes
Trial Locations
- Locations (1)
London Health Sciences Centre
🇨🇦London, Ontario, Canada