Effect of Heartfulness Meditation Practice on Mitochondrial Function: A Biochemical and Genomic Approach
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- 1. Mean Loneliness Score,
研究概览
简要总结
Mitochondrial dysfunction is increasingly recognized as a key factor in various socioeconomic and health challenges, including neurodegenerative diseases, cardiovascular disorders, and metabolic syndromes. Psychological stress, prevalent in modern society, has been linked to mitochondrial impairment, exacerbating these conditions. This research focuses on investigating the potential health benefits of yoga and meditation, particularly Heartfulness meditation, in reducing stress-induced mitochondrial dysfunction. Addressing these impacts can significantly improve public health outcomes, especially in stress-prone populations, while also easing the burden on healthcare systems.
Mitochondria play a crucial role in cellular energy production, apoptosis, and managing oxidative stress. Their health is vital for maintaining overall physiological functions. Any alteration, such as mitochondrial fragmentation or oxidative damage, can lead to the progression of chronic diseases. Therefore, safeguarding mitochondrial integrity is essential for preventing and managing a wide range of diseases. Mitochondrial biogenesis and the balance between free radicals and antioxidants are also fundamental aspects of health that can be influenced by lifestyle and stress management practices.
Yoga and meditation, especially Heartfulness techniques, have shown promise in enhancing mitochondrial health. These practices can reduce oxidative stress, promote DNA repair, and improve mitochondrial function through psycho-neuro-immune regulation. This study will investigate the effects of Heartfulness meditation on mitochondrial integrity through biochemical and genomic analyses, offering a scientific basis for its role in disease prevention and health promotion.
Through this research, we aim to provide evidence on how regular Heartfulness meditation may improve mitochondrial function, offering a potential therapeutic intervention for stress-related disorders. The study will highlight its capacity to promote cellular health and well-being, providing valuable insights for integrating mind-body practices into public health initiatives.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 25.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •participants will be from the age group 25-40 years, healthy (with no history of bacterial/viral/fungal infections in the past two months, no co-morbidities like diabetes, hypertension, PCOS/PCOD, etc.).
排除标准
- •Dropout meditators unwilling to continue the practice or unable to do daily practice, attend group meditation session and individual session from 3 to 4 weeks Individuals with chronic conditions affecting mitochondrial function (e.g., diabetes, Hypertension, neurodegenerative diseases and cvd).
- •Participants performing other yoga and meditation like brahma kumari, mindfulness, kriya yoga, Sahaj Yog etc.
- •Inability to read or comprehend the consent form; subjects with medical conditions in which a blood draw would be contraindicated (e.g., severe anaemia); use of antibiotics or probiotic/prebiotic participants living outside of the country.
结局指标
主要结局
1. Mean Loneliness Score,
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
2. Mean Gratitude Score,
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
3. Mean Self-Consciousness Score,
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
4. Mean Comprehensive Intellectual Humility Score
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
5. Mean Well-being Score
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
6. Mean Burnout Score
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
7. Nicotinamide adenine dinucleotide (NAD/NAD+) and Cytochrome c Oxidase levels
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
8. Mitochondrial DNA copy number
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
9. Gene expression of key mitochondrial markers.
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
10. Mitochondrial membrane potential
时间窗: This cross-sectional observational study involves the collection of blood samples from participants at a single point in time ie. Baseline. Blood samples will be analyzed to assess specific biomarkers relevant to the study objectives.
次要结局
- Meditation, particularly practices like Heartfulness, has been associated with enhanced mitochondrial function, offering insights into its cellular benefits. Studies show increased ATP production in meditators, indicating more efficient energy synthesis. Additionally, reduced oxidative stress and upregulated mitochondrial gene expression suggest improved cellular resilience and regulation. These biological changes reflect better mitochondrial health, serving as a potential mechanism underlying the broad health benefits of meditation. The findings deepen our understanding of how mind-body practices impact cellular function and open avenues for integrating meditation into therapeutic strategies to promote overall well-being by targeting mitochondrial efficiency and cellular homeostasis(After one year)
研究者
Dr Mansee Thakur
MGM School of Biomedical Sciences, MGMIHS