Immune Profile of Acute VKH Patients PBMC

• Conditions: VKH Syndrome
• Interventions: Drug: Steroids

• Registration Number: NCT04025476
• Lead Sponsor: Aier School of Ophthalmology, Central South University

Brief Summary

The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-07
• Study First Submitted: 2019-07-14
• Study First Submitted QC: 2019-07-16
• Study First Posted: 2019-07-19
• Last Update Submitted: 2019-07-19
• Study Start: 2019-07-20
• Last Update Posted: 2019-07-22
• Primary Completion: 2021-12-31
• Study Completion: 2022-07-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1. Acute VKH patients, meet a criterion of VKH, no recurrence.
2. Age range from 18 to 50 years old.

Exclusion Criteria

1. Patients with Severe Cardiovascular and Cerebrovascular Diseases
2. Patients allergic to steroid or contrast agents;
3. A history of ocular trauma or intraocular surgery within 3 months; Vaccinated; History of infectious diseases
4. having a history of heredity, immune system correlation, neuroendocrine and digestive system diseases
5. Patients who take health care products for a long time and have heavy alcohol and tobacco addiction.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
VKH patients	Steroids	acute VKH patients

Primary Outcome Measures

Name	Time	Method
T/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients	one year	use flow cytometry to count T/B /NK/monocyte...etc, cell numbers
T/B /NK/monocyte...etc cell functional change in VKH patients	one year	use ELISA(enzyme linked immunosorbent assay) to measure inflammatory cytokines level in peripheral blood
T/B /NK/monocyte...etc cell subtype proportion in blood samples in VKH patients	one year	use flow cytometry to measure T/B /NK/monocyte...etc cell subtype proportion

Secondary Outcome Measures

Name	Time	Method
measure the Injury degree of choroid and retinal vessels	one year	Use FFA(fluorescein fundus angiography)/ICG(Indocyanine Green Angiography) to measure the Injury degree of choroid and retinal vessels
choroid and retinal thickness change in different course of VKH patients	one year	Use OCT（optical coherence tomography） to measure choroid and retina thickness changes in macular zone of different course VKH patients
Use OCTA(optical coherence tomography angiography) to measure macular and optic disc vascular index	one year	Use OCTA to measure macular and optic disc vascular index in different course VKH patients
Use Maia perimeter to measure macular integrality	one year	Use Maia perimeter to measure macular integrality including light threshold and central fixation.

Trial Locations

Locations (1)

Wuhan Aier eye hospital; 🇨🇳 Wuhan, Hubei, China