Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects

Completed

• Conditions: Healthy
• Interventions: Other: Air pollution study on healthy volunteers.

• Registration Number: NCT01042834
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

Detailed Description

The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2010-01-05
• Study First Submitted QC: 2010-01-05
• Study First Posted: 2010-01-06
• Primary Completion: 2010-07
• Study Completion: 2010-07
• Status Verified: 2011-01
• Last Update Submitted: 2011-01-12
• Last Update Posted: 2011-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• reside in Lyon and Saint-Etienne cities
• security social affiliated or beneficiary
• information note signed

Exclusion Criteria

• heart rate disorders
• pacemaker
• tabacco addiction or second-hand smoke
• morbid obesity (BMI > 30)
• insulin-dependent diabetes
• chronic disease on treatment
• antiarrythmic treatments

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Air pollution	Air pollution study on healthy volunteers.	The subjects will have to live in districts where important atmospheric pollution is established

Primary Outcome Measures

Name	Time	Method
Frequency analysis of heart rate variability	inclusion, 1 test night and 2 experimental nights

Secondary Outcome Measures

Name	Time	Method
Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality.	1 test night and 2 experimental nights
Hour index quantification of night respiratory events.	1 test night and 2 experimental nights
Hour index quantification of autonomic awakening during the sleep.	1 test night and 2 experimental nights

Trial Locations

Locations (2)

CHU Saint-Etienne; 🇫🇷 Saint-Etienne, France

Hospices Civiles de Lyon; 🇫🇷 Lyon, France