NCT00439530已完成1 期
Pharmacologic Study of Oseltamivir in Healthy Volunteers
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- AUC 0-12 hrs.
研究概览
简要总结
"Pharmacologic Study of Oseltamivir in Healthy Volunteers" is a Phase I study in which 8 to 32 adult healthy Thai volunteers will be randomized to one of four drug doses and regimens within each of 4 visits. The study is being conducted at the Bangkok Hospital of Tropical Diseases Research Unit, Faculty of Tropical Medicine, and commenced enrolling healthy volunteers on 23 November 2006. The duration of the study is expected to be approximately four months. The goals of this study are to assess the use of loading dose oseltamivir and the concomitant use of probenecid and to characterize the pharmacokinetic properties of oseltamivir in Thai subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy with no underlying chronic disease
- •normal baseline laboratory screening
- •no regular prescribed medication used in the past 30 days and no over-the-counter medication in the past week
- •agree to abstain from self-medication during the study
- •negative urine pregnancy test for females and agreement that they will not try to become pregnant until 1 month after the study is completed
- •only use non-hormonal methods of contraception for females
- •non-smoker for the last 30 days and for duration of the study
- •no consumption of alcohol for the last 30 days and for duration of the study
- •no use of recreational drugs for the last 30 days and for duration of the study
排除标准
- •known hypersensitivity to oseltamivir and/or probenecid
- •Hepatitis B virus surface antigen positive
- •presence of intercurrent illness or any condition which in the judgement of the investigator would place the subject at undue risk or interfere with the results of the study
结局指标
主要结局
AUC 0-12 hrs.
时间窗: 12 hour
次要结局
- AUC 12-24 hrs.(24 hrs)
- C max(24 hrs)
- t max(24 hrs)
- t 1/2(24 hrs)
研究者
研究点 (2)
Loading locations...
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