COMPARATIVE EVALUATION OF IL-1 beta LEVELS IN GINGIVAL CREVICULAR FLUID AROUND CAD - CAM FABRICATED PEEK CROWNS AND POLISHED ZIRCONIA CROWNS - AN IN VIVO STUDY
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 16
- 试验地点
- 1
研究概览
简要总结
Fixed dental prostheses aim to replace missing teeth while maintaining periodontal health, function and aesthetics. Due to increasing aesthetic demands and concerns about the biocompatibility of metal alloys, all-ceramic crowns -especially zirconia- highly popular. Zirconia offers excellent strength, biocompatibility, soft tissue response, and anti-microbial properties. Polyetherethrketone (PEEK), a member of PEAK family, has recently emerged as a promising alternative crown material. It has good stress modulation, minimal abrasion, stable color, making it a potential substitute of zirconia crowns. Restorative materials may influence periodontal tissues as well as gingival crevicular fluid (GCF). As GCF contains several inflammatory biomarkers such as interleukin-1 beta, interleukin-6, interleukin-8, tumor necrosis factor-alpha and matrix metalloproteinase-8, which are indicators of periodontal inflammation and tissue degradation products from restorative materials. There are numerous studies have explored gingival biomarkers levels in relation to various permanent crowns, there is limited research on how PEEK crowns influence Gingival inflammation and biomarker expression.
Therefore, this study is designed to study the effect of PEEK crowns fabricated using CAD-CAM on periodontal health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 24.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients requiring bilaterally posterior mandibular complete crowns.
- •Teeth selected for Permanent CAD/CAM crowns preparation should be restorable with a minimum crown to root ratio of at least 1:
- •Patients with good oral hygiene and periodontal status.
- •Patients with full complement of teeth (excluding 3rd molars).
- •Patients who will be available for the required follow up period.
- •Patients giving positive informed consent.
- •Patients with plaque index less than 15 percent, bleeding index less than 10 percent.
排除标准
- •Patients with developmental defects of enamel and dentin.
- •2.Patients with systemic disease (e.g, diabetic mellitus, hypertension, cancer, Sjogren’s syndrome etc.)
- •Habitual tobacco smokers.
- •Untreated gingival or periodontal disease
- •Parafunctional habits like bruxism, clenching.
研究者
Tadu konya
All india institute of medical sciences