Red Blood Cell Distribution Width as a Predictor Marker of Contrast Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 入组人数
- 126
- 主要终点
- Contrast Induced Nephropathy
研究概览
简要总结
Contrast Induced Nephropathy is an acute renal insufficiency defined as a 25% or 0.5 mg/dl increase over the baseline of the serum creatinine level 24 h to 72 h after intravascular administration of a contrast agent.
详细描述
Contrast Induced Nephropathy has been introduced an important complication after coronary angiography and Percutaneous Coronary Intervention .
The development of Contrast Induced Nephropathy after Percutaneous Coronary Intervention is associated with poor clinical outcomes including prolonged hospitalization, increased costs, increased rates of end-stage renal failure, myocardial infarction, repeat revascularization, and short- and long-term mortality.
Contrast Induced Nephropathy follows decreased renal perfusion and administration of nephrotoxic medications as the third most common cause of renal insufficiency during hospitalization.
Patients with acute coronary syndrome have a 3-fold higher risk of developing Contrast Induced Nephropathy .Therefore ,predicting contrast nephropathy and initiating therapeutic preventive strategies are very important.
Red Blood Cell Distribution Width is a quantitive marker of the variability on size of erythrocyte.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients who underwent percutaneous coronary intervention either elective or emergency.
排除标准
- •End stage renal disease with glomerular filtration rate less than 30 ml/1.
- •Patient known allergy to contrast agents.
- •Left ventricular ejection fraction below 30%.
- •Presence of infection
- •A recent history of contrast administration in the previous month.
- •Patient known to have thyroid disease.
- •History of malignancy.
- •Patient known to have Autoimmune disease.
- •Decompensated liver cirrhosis
- •Cardiogenic shock.
结局指标
主要结局
Contrast Induced Nephropathy
时间窗: 48 Hours
Percentage of patients with raised serum creatinine 25% or 0.5 mg/dl over baseline serum creatinine within 48 hour after contrast administration
次要结局
未报告次要终点
研究者
Sherly Boshra
Principal Investigator
Assiut University