Effects of Red Blood Cells Transfusion on Renal Resistivity Index and Renal Venous Stasis Index
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Università degli Studi di Ferrara
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Change Renal Venous Stasis Index (RSVI) after intervention
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound
Investigators
Alberto Fogagnolo
Principal Investigator
Università degli Studi di Ferrara
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 and \< 90
- •Hemoglobin ≥7 and ≤ 10 g/dl
Exclusion Criteria
- •Ultrasound RRI evaluation non available
- •Patients with arrhythmia
- •Pregnancy
- •Refusal to give consent
- •History of renal transplantation
- •Central venous access in superior vena cava not available Critical active bleeding
Outcomes
Primary Outcomes
Change Renal Venous Stasis Index (RSVI) after intervention
Time Frame: after 60 minute from intervention
To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome.
Change in renal resistivity index (RRI) after intervention
Time Frame: after 60 minute from intervention
To compare change in RRI after intervention between groups. Values over\>0.70 are considered pathological. Higher values means worse outcome.
Secondary Outcomes
- Variation in Renal Venous Stasis Index (RSVI)(after 24 hours from intervention)
- Occurence of AKI(Once a day for 7 days)
- Variation in renal resistivity index (RRI)(after 24 hours from intervention)