Effects of Red Blood Cells Transfusion on Renal Resistivity Index and Renal Venous Stasis Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Change Renal Venous Stasis Index (RSVI) after intervention
研究概览
简要总结
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 and < 90
- •Hemoglobin ≥7 and ≤ 10 g/dl
排除标准
- •Ultrasound RRI evaluation non available
- •Patients with arrhythmia
- •Pregnancy
- •Refusal to give consent
- •History of renal transplantation
- •Central venous access in superior vena cava not available Critical active bleeding
结局指标
主要结局
Change Renal Venous Stasis Index (RSVI) after intervention
时间窗: after 60 minute from intervention
To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome.
Change in renal resistivity index (RRI) after intervention
时间窗: after 60 minute from intervention
To compare change in RRI after intervention between groups. Values over\>0.70 are considered pathological. Higher values means worse outcome.
次要结局
- Variation in Renal Venous Stasis Index (RSVI)(after 24 hours from intervention)
- Occurence of AKI(Once a day for 7 days)
- Variation in renal resistivity index (RRI)(after 24 hours from intervention)
研究者
Alberto Fogagnolo
Principal Investigator
Università degli Studi di Ferrara