PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 2
- 主要终点
- Occurence of AKI
研究概览
简要总结
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted to ICU with expected mechanical ventilation >48h
排除标准
- •Ultrasound RRI evaluation non available
- •Patients with arrhythmia
- •Pregnancy
结局指标
主要结局
Occurence of AKI
时间窗: once a day until day 7
AKI will be defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria
次要结局
- Change in RRI at different level of PEEP(One a day until day 5)
研究者
Alberto Fogagnolo
Principal investigator
Università degli Studi di Ferrara
