PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Distress Syndrome, Adult
- Sponsor
- Università degli Studi di Ferrara
- Enrollment
- 105
- Locations
- 2
- Primary Endpoint
- Occurence of AKI
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI
Investigators
Alberto Fogagnolo
Principal investigator
Università degli Studi di Ferrara
Eligibility Criteria
Inclusion Criteria
- •Patients admitted to ICU with expected mechanical ventilation \>48h
Exclusion Criteria
- •Ultrasound RRI evaluation non available
- •Patients with arrhythmia
- •Pregnancy
Outcomes
Primary Outcomes
Occurence of AKI
Time Frame: once a day until day 7
AKI will be defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria
Secondary Outcomes
- Change in RRI at different level of PEEP(One a day until day 5)