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Clinical Trials/NCT03969914
NCT03969914
Completed
Not Applicable

PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury

Università degli Studi di Ferrara2 sites in 1 country105 target enrollmentMay 1, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Respiratory Distress Syndrome, Adult
Sponsor
Università degli Studi di Ferrara
Enrollment
105
Locations
2
Primary Endpoint
Occurence of AKI
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI

Registry
clinicaltrials.gov
Start Date
May 1, 2019
End Date
June 15, 2020
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Università degli Studi di Ferrara
Responsible Party
Principal Investigator
Principal Investigator

Alberto Fogagnolo

Principal investigator

Università degli Studi di Ferrara

Eligibility Criteria

Inclusion Criteria

  • Patients admitted to ICU with expected mechanical ventilation \>48h

Exclusion Criteria

  • Ultrasound RRI evaluation non available
  • Patients with arrhythmia
  • Pregnancy

Outcomes

Primary Outcomes

Occurence of AKI

Time Frame: once a day until day 7

AKI will be defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria

Secondary Outcomes

  • Change in RRI at different level of PEEP(One a day until day 5)

Study Sites (2)

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