To study the usefulness of von willibrand factor to ADAMTS-13 ratio as a predictor of development of extrahepatic organ failure in acute on chronic liver failure patients.
Not Applicable
- Conditions
- Health Condition 1: K768- Other specified diseases of liver
- Registration Number
- CTRI/2023/10/058349
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All the patients with age >18 years who are diagnosed having ACLF fulfilling APASL ACLF criteria and do not have any extrahepatic organ failure at enrollment.
Exclusion Criteria
1) Patients on antiplatelet or anticoagulant therapy for at any point of time in last 7 days
2) Pregnant female
3) Patient receiving N-acetyl cysteine (NAC) (interferes with the vWF assay)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of patients developing of any organ failures by day 7 with increased vWF: ADAMTS 13 ratioTimepoint: Day 7
- Secondary Outcome Measures
Name Time Method Proportion of patients having change in vWF, ADAMTS 13 level and vWF Ag : ADAMTS-13 ratio at day 7 different therapies (Nutrition, Plasma exchange, Prednisolone, Nucleos(t)ide analogue in hepatitis B) on vWF, ADAMTS 13 level and vWF Ag : ADAMTS-13 ratio.Timepoint: Day 28;Proportion of patients having change in vWF, ADAMTS 13 level and vWF Ag : ADAMTS-13 ratio compared to change in AARC, MELD, CLIF-ACLF scoresTimepoint: Day 28;Proportion of patients with increased vWF, ADAMTS 13 level and vWF Ag : ADAMTS-13 ratio across different grades of AARC ACLFTimepoint: Day 28;Proportion of patients alive by day 28 without transplant with increased day 1 and day 4 vWF and ADAMTS 13 levelTimepoint: Day 28;Proportion of patients alive by day 28 without transplant with increased vWF: ADAMTS 13 ratioTimepoint: Day 28;Proportion of patients developing of any organ failures by day 7 with increased day 1 and day 4 vWF and ADAMTS 13 levelTimepoint: Day 7