The effect of arterial oxygen content on mitoPO2 in healthy human volunteers

Completed

• Conditions: Beademing; mitochondria; lack of oxygen; 10038716; 10011954

• Registration Number: NL-OMON52136
• Lead Sponsor: OLVG

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 9

Inclusion Criteria

Age 18-30 years
healthy participants: absence of active or chronic disease, not taking
medication
BMI 18-25kg/m2

Exclusion Criteria

Participation in an investigational drug study within 3 months prior to
screening
Allergy to plaster adhesives
History of photo dermatosis or porphyria
High altitude exposure in previous 3 months >1500m
Active smoking
History of cardiovascular disease
family history of myocardial infarction with age < 50 years
Evidence of conduction abnormalities or previous myocardial ischemia on EKG

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in mitoPO2 and mitochondrial oxygen consumption at several oxygen<br /><br>saturations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To determine whether ALA-uptake in the skin can be enhanced by using a<br /><br>dermaroller<br /><br>2. To determine the effect of hyperoxia and hypoxia on markers of mitochondrial<br /><br>function and their relation to mitoPO2.</p><br>