Virus interactions in the respiratory tract; a cohort study with childre
Recruiting
- Conditions
- Respiratory infections10047438
- Registration Number
- NL-OMON54063
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 225
Inclusion Criteria
Age older than 6 weeks and less than 4 years
AND
1) have older siblings or 2) attend daycare.
AND
Live within 30 minutes drive from UMCU (by car) and have access to a fever
thermometer
Exclusion Criteria
recurrent respiratory tract infections and are treated with antibiotic
profylaxis
OR
known immunodeficiency
OR
chronic lung disease that increases susceptibility to infection (e.g. cystic
fibrosis)
OR
congenital anomalies of the airways
Parents/guardians have insufficient comprehension of Dutch language (all study
communication and questionnaires are in Dutch language)
A sibling already participating in the study
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>(Co-)occurrence, timing and virus species of respiratory infection as detected<br /><br>by PCR analysis of weekly nasal swab specimens.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Presence and severity of respiratory and systemic symptoms compatible with<br /><br>virus infection. Occurrence of acute respiratory illness (ARI) is based on<br /><br>daily symptom monitoring. </p><br>