Effect of respiratory syncytial viral infection on the microbiome of the upper respiratory tract * a controlled human infection study

• Conditions: bronchiolitis; RSV respiratory tract infection; 10047438; 10024970

• Registration Number: NL-OMON51223
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

1. Healthy males or females
2. Age 18-55 years
3. Signed and dated informed consent form

Exclusion Criteria

1. Child <3 years living in subject's househould
2. Elderly > 65 years old living in subject*s household
3. Presence of significant acute or chronic medical illness that is associated
with increased risk of respiratory viral illness related complications. These
include but are not limited to:
a. Recent (within adulthood) history of asthma, COPD, hypertension, reactive
airway disease, or any other chronic lung illness
b. History or evidence of impaired immune responsivity or autoimmune disease
c. Confirmed hepatitis B (HBV), human immunodeficiency virus (HIV), or
hepatitis C (HCV) test

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The Mean Shannon index measured in healthy subjects and in subjects after RSV<br /><br>infection. </p><br>