MRI Maker of Perioperative Neurocognitive Disorder
- Conditions
- Knee OsteoarthritisNecrosis of Femoral HeadFracture of Lower Limb
- Registration Number
- NCT03773627
- Lead Sponsor
- RenJi Hospital
- Brief Summary
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Age ≥ 60 years
- Spoke proficient Chinese
- Selected to lower limb osteopathic surgery
- Informed consent signed by the patient
- Underwent general anesthesia
Exclusion Criteria
- Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- With standard contraindications to MRI examinations
- Unwillingness to comply with the protocol or procedures.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MRI markers of PND before 7th day after surgery From the day before surgery to the 7th day after surgery To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery
- Secondary Outcome Measures
Name Time Method MRI markers of PND before 12 month after surgery From the 7th day after surgery to 12 month after surgery To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 12 months after surgery
Trial Locations
- Locations (1)
Renji Hospital
🇨🇳Shanghai, Shanghai, China