NCT03773627
Unknown
Not Applicable
MRI Marker of Postoperative Delirium and Delayed Neurocognitive Recovery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Necrosis of Femoral Head
- Sponsor
- RenJi Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- MRI markers of PND before 7th day after surgery
- Last Updated
- 7 years ago
Overview
Brief Summary
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 60 years
- •Spoke proficient Chinese
- •Selected to lower limb osteopathic surgery
- •Informed consent signed by the patient
- •Underwent general anesthesia
Exclusion Criteria
- •Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
- •Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- •Several audition or vision disorder
- •With standard contraindications to MRI examinations
- •Unwillingness to comply with the protocol or procedures.
Outcomes
Primary Outcomes
MRI markers of PND before 7th day after surgery
Time Frame: From the day before surgery to the 7th day after surgery
To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery
Secondary Outcomes
- MRI markers of PND before 12 month after surgery(From the 7th day after surgery to 12 month after surgery)
Study Sites (1)
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