NCT03773627Unknown不适用
MRI Marker of Postoperative Delirium and Delayed Neurocognitive Recovery
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- MRI markers of PND before 7th day after surgery
研究概览
简要总结
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 60 years
- •Spoke proficient Chinese
- •Selected to lower limb osteopathic surgery
- •Informed consent signed by the patient
- •Underwent general anesthesia
排除标准
- •Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
- •Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- •Several audition or vision disorder
- •With standard contraindications to MRI examinations
- •Unwillingness to comply with the protocol or procedures.
结局指标
主要结局
MRI markers of PND before 7th day after surgery
时间窗: From the day before surgery to the 7th day after surgery
To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery
次要结局
- MRI markers of PND before 12 month after surgery(From the 7th day after surgery to 12 month after surgery)
研究者
研究点 (1)
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