Does yoga regulate the miRNA levels in persons with epilepsy?
Phase 2
- Conditions
- Health Condition 1: G400- Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onsetHealth Condition 2: G402- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizuresHealth Condition 3: G401- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizuresHealth Condition 4: G408- Other epilepsy and recurrent seizures
- Registration Number
- CTRI/2021/02/031455
- Lead Sponsor
- DST
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) Consenting
b) Persons diagnosed as having active epilepsy.
c) Age greater than 18 years, but less than 60 years.
d) Patients with clinically diagnosed temporal lobe or temporal plus epilepsy
e) Patients who have had at least one seizure in the past one month
Exclusion Criteria
a) Non-Consenting
b) Actively or previously practicing meditation/ yoga for a period of three months or longer
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the changes in levels of microRNAs implicated in epilepsy after a 12 week yoga-meditation based intervention as compared to a sham yoga protocolTimepoint: baseline, 8 weeks, 12 weeks
- Secondary Outcome Measures
Name Time Method To evaluate the efficacy of these intervention modules in decreasing neuro-psychological comorbidity as assessed by Generalized Anxiety Disorder Scale-7 (GAD-7), Patient Health <br/ ><br>Questionnaire-9 (PHQ-9) and Quality of Life (QoLIE-10)Timepoint: Baseline, 12 weeks, 6 months;To evaluate the efficacy of these interventions in improving electroencephalographic, namely spectral intensity as recorded by a high-density (128 <br/ ><br>channel) EEG.Timepoint: Baseline, 12 weeks;To evaluate the efficacy of these interventions in reducing the seizure frequency and severity as <br/ ><br>recorded on a seizure diaryTimepoint: Baseline, 8 weeks, 12 weeks, 6 months