BRAF V600E Mutations In Papillary Thyroid Carcinoma

Early Phase 1

• Conditions: Papillary Thyroid Carcinoma
• Interventions: Genetic: BRAF V600E POSITIVITY

• Registration Number: NCT01417442
• Lead Sponsor: Bezmialem Vakif University

Brief Summary

The purpose of this study is to determine whether BRAF V600E mutation in our patients with papillary thyroid cancer has an association with poor prognosis.

Detailed Description

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy and BRAF V600E mutation is the most common genetic alteration identified in PTC, ranging from 25 to 80%, with the average rate about 45%. Various studies demonstrated a relationship between BRAF V600E mutation and aggressive characteristics of the cancer, including the worse patient prognosis. But,there are no studies from Turkey regarding this topic. So the investigators will examine BRAF V600E mutation in our patients with PTC and try to assess the role of this mutation in prognosis and further management of the patients.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-07-06
• Status Verified: 2011-08
• Study First Submitted QC: 2011-08-13
• Last Update Submitted: 2011-08-13
• Study First Posted: 2011-08-16
• Last Update Posted: 2011-08-16
• Primary Completion: 2012-07
• Study Completion: 2012-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Patients with papillary thyroid cancer

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Exclusion Criteria

• Patients who do not want to be a part of this study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
BRAF V600E POSITIVITY	BRAF V600E POSITIVITY	This mutation will be analysed using the tumor tissues of the patients operated for thyroid diseases and diagnosed with papillary thyroid carcinoma. And mutation positive patients will be investigated for the aggressive characteristics of the tumor.

Primary Outcome Measures

Name	Time	Method
BRAF V600E MUTATION	2 years

Trial Locations

Locations (1)

Yeliz Emine Ersoy; 🇹🇷 Istanbul, Turkey