Can an alternative type of intracytoplasmic sperm injection (ICSI) improve fertilisation?

Not Applicable

• Conditions: Infertility; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12620000407998
• Lead Sponsor: Monash IVF Group Limited

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-03-26
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 151

Inclusion Criteria

1.Any patient for whom ICSI is the clinical management instruction will be eligible where the semen collection method is ejaculation.

2.Patients with equal to or greater than 6 mature eggs for injection post egg retrieval.

Exclusion Criteria

1.Cycles involving frozen or surgical retrieved sperm.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fertilization rate. <br>Outcome assessed: Laboratory analysis for the presence of 2 pronuclear embryo under microscopic observations.[ 14-16 h post ICSI.]

Secondary Outcome Measures

Name	Time	Method
Egg (oocyte) degeneration rate. <br>Outcome assessed: Laboratory analysis for lysis rates of eggs under microscopic observations.[ Up to 1 hr post ICSI.];Embryo development<br>Outcome assessed: Laboratory analysis for on time embryo development under microscopic observations.[ Day 3, 4 and day 5 embryo developmental scoring.];Embryo utilisation.<br>Outcome assessed: Assessment of medical records from the embryology laboratory to determine the number of embryos frozen/transferred during current treatment cycle.[ 1 week post ICSI insemination.]