Intracytoplasmatic Sperm Injection using testicular spermatozoa in men with azoospermia; an observational study with follow-up of the offspring.

Completed

• Conditions: birthdefect; congenital malformations; 10027664; 10018188; 10038612

• Registration Number: NL-OMON35132
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 2065

Inclusion Criteria

Azoospermia, trying to conceive

Exclusion Criteria

Contraindication for ICSI treatment

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage congenital malformations, neurological- and behaviour problems in<br /><br>children born after TESE</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The percentage of TESE procedures in which usuable spermatozoa are found (the<br /><br>sperm retrieval rate [SRR])<br /><br>- The number of ICSI procedures per TESE<br /><br>- The fertilization rate<br /><br>- Clinical pregnancy per patient with a azoospermia<br /><br>- Ongoing pregnancy rate per patient with a azoospermia<br /><br>- Ongoing pregnancies per TESE procedure<br /><br>- Number of life births per TESE<br /><br>- Clinical pregnancy rate per ICSI cycle<br /><br>- Ongoing pregnancy rate per ICSI cycle<br /><br>- Miscarriage rate per ICSI cycle<br /><br>- Complications after TESE: infection, bleeding, pain and decrease of<br /><br>testosterone level</p><br>